Detalhe da pesquisa
1.
Horizontal Cell Biology: Monitoring Global Changes of Protein Interaction States with the Proteome-Wide Cellular Thermal Shift Assay (CETSA).
Annu Rev Biochem
; 88: 383-408, 2019 06 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-30939043
2.
Modulation of Protein-Interaction States through the Cell Cycle.
Cell
; 173(6): 1481-1494.e13, 2018 05 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-29706543
3.
Understanding transport by the major facilitator superfamily (MFS): structures pave the way.
Nat Rev Mol Cell Biol
; 17(2): 123-32, 2016 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-26758938
4.
IMPRINTS.CETSA and IMPRINTS.CETSA.app: an R package and a Shiny application for the analysis and interpretation of IMPRINTS-CETSA data.
Brief Bioinform
; 25(3)2024 Mar 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-38557673
5.
Deep learning enables the discovery of a novel cuproptosis-inducing molecule for the inhibition of hepatocellular carcinoma.
Acta Pharmacol Sin
; 45(2): 391-404, 2024 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-37803139
6.
Recent advances in proteome-wide label-free target deconvolution for bioactive small molecules.
Med Res Rev
; 41(6): 2893-2926, 2021 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-33533067
7.
New ideas for non-animal approaches to predict repeated-dose systemic toxicity: Report from an EPAA Blue Sky Workshop.
Regul Toxicol Pharmacol
; 114: 104668, 2020 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-32335207
8.
The Cellular Thermal Shift Assay: A Novel Biophysical Assay for In Situ Drug Target Engagement and Mechanistic Biomarker Studies.
Annu Rev Pharmacol Toxicol
; 56: 141-61, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-26566155
9.
A saposin-lipoprotein nanoparticle system for membrane proteins.
Nat Methods
; 13(4): 345-51, 2016 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-26950744
10.
Structural analyses of human thymidylate synthase reveal a site that may control conformational switching between active and inactive states.
J Biol Chem
; 292(32): 13449-13458, 2017 08 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-28634233
11.
Structure of the Open Reading Frame 49 Protein Encoded by Kaposi's Sarcoma-Associated Herpesvirus.
J Virol
; 91(2)2017 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27807232
12.
Molecular insights into substrate recognition and catalytic mechanism of the chaperone and FKBP peptidyl-prolyl isomerase SlyD.
BMC Biol
; 14(1): 82, 2016 Sep 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-27664121
13.
Crystal Structures of Type-II Inositol Polyphosphate 5-Phosphatase INPP5B with Synthetic Inositol Polyphosphate Surrogates Reveal New Mechanistic Insights for the Inositol 5-Phosphatase Family.
Biochemistry
; 55(9): 1384-97, 2016 Mar 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-26854536
14.
Structure of the C-Terminal Domain of the Multifunctional ICP27 Protein from Herpes Simplex Virus 1.
J Virol
; 89(17): 8828-39, 2015 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-26085142
15.
VP22 core domain from Herpes simplex virus 1 reveals a surprising structural conservation in both the Alpha- and Gammaherpesvirinae subfamilies.
J Gen Virol
; 96(Pt 6): 1436-1445, 2015 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-26068188
16.
Structural insights into substrate recognition in proton-dependent oligopeptide transporters.
EMBO Rep
; 14(9): 804-10, 2013 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-23867627
17.
The crystal structure of the DNA-binding domain of vIRF-1 from the oncogenic KSHV reveals a conserved fold for DNA binding and reinforces its role as a transcription factor.
Nucleic Acids Res
; 41(7): 4295-306, 2013 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-23435230
18.
High-throughput analytical gel filtration screening of integral membrane proteins for structural studies.
Biochim Biophys Acta
; 1830(6): 3497-508, 2013 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-23403133
19.
Structural basis for PTPA interaction with the invariant C-terminal tail of PP2A.
Biol Chem
; 395(7-8): 881-9, 2014 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-25003389
20.
Deep learning based CETSA feature prediction cross multiple cell lines with latent space representation.
Sci Rep
; 14(1): 1878, 2024 01 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-38253642